Functions of some Replication fork proteins in E. coli and mammals
E. Coli SV40/Human Functions
dnaB T antigen DNA helicase; stimulates priming
dnaC T antigen primosome assembly
SSB RPA single strand binding protein
gamma complex RFC DNA dependent ATPase - loads clamp
tau ? dimerization of holoenzyme (pol*)
beta PCNA processivity factor
PolIII core pol sigma DNA polymerase; 3’-5’ exonuclease
---------- Pol alpha limited DNA synthesis at origin, lagging strand
dnaG Primase primes ss DNA
PolI FEN-1 or MF-1 Nuclease- removes primers