Enhancers determine the temporal and spatial transcription patterns of genes(drawing modified from Tijan, R., Molecular Machines That Control Genes, Scientific American 272, Feb, 1995)

Activators = + Auxiliary Transcription Factors

Enhancers

Silencer

Repressor = -

auxiliary transcription

factor

Co-activators

TATA BOX

REPRESSOR

CORE PROMOTER

transcription

Basal Transcription

Factors

RNA Polymerase

H

E

F

B

A

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