PPT Slide

Genital Ridge

Bipotential

Gonad

SRY

Wnt4a

Testis

SF1

Sertoli Cells

Leydig Cells

testosterone

anti-Mullerian

hormone

SF1

Ovary

Follicular Cells

Theca Cells

Follicles

Mullerian duct

Female internal

genitalia

(uterus, oviduct,

cervix, upper vagina)

regression

dihydrotestosterone

Wolffian duct

Male internal genitalia

(epididymus, vas deferens, seminal vesicle)

Male external genitalia

Cascades of

Mammalian Sex

Determination

(after Gilbert)

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