Figure
2, Operator DNA Sequences. 2a, above. The DNA sequence of each 17 base
pair operator sequence in a genetic switch region of bacteriophage lambda.
The operators (OR1, OR2, and OR3) each comprise
palindromic
sequences, found in left and right half-sites centered
on a 2-fold symmetry axis.
The middle of the palindromes lie ~10 base pairs (~34 angstroms apart.
This spacing of partial palindromes provides the monomers of a dimeric
cro or repressor protein nearly identical binding sites
in each operator, separated by one complete turn of B-DNA. |